A road map for the treatment of pediatric diffuse midline glioma

Carl Koschmann; Wajd N Al-Holou; Marta M Alonso; Jamie Anastas; Pratiti Bandopadhayay; Tara Barron; Oren Becher; Rodrigo Cartaxo; Maria G Castro; Chan Chung; Madison Clausen; Derek Dang; Robert Doherty; Ryan Duchatel; Matthew Dun; Mariella Filbin; Andrea Franson; Stefanie Galban; Marc Garcia Moure; Hugh Garton; Pruthvi Gowda; Joana Graca Marques; Cynthia Hawkins; Allison Heath; Esther Hulleman; Sunjong Ji; Chris Jones; Lindsay Kilburn; Cassie Kline; Michael A Koldobskiy; Daniel Lim; Pedro R Lowenstein; Q Richard Lu; Joanna Lum; Stephen Mack; Suresh Magge; Bernard Marini; Donna Martin; Neena Marupudi; Dana Messinger; Rajen Mody; Meredith Morgan; Mateus Mota; Karin Muraszko; Sabine Mueller; Siva Kumar Natarajan; Javad Nazarian; Michael Niculcea; Nicholas Nuechterlein; Hideho Okada; Valerie Opipari; Manjunath P Pai; Sharmistha Pal; Erik Peterson; Timothy Phoenix; John R Prensner; Matthew Pun; G Praveen Raju; Zachary J Reitman; Adam Resnick; David Rogawski; Amanda Saratsis; Stefanie G Sbergio; Mark Souweidane; James M Stafford; Theophilos Tzaridis; Sujatha Venkataraman; Orazio Vittorio; Jack Wadden; Daniel Wahl; Robert J Wechsler-Reya; Viveka Nand Yadav; Xu Zhang; Qiang Zhang; Sriram Venneti

doi:10.1016/j.ccell.2023.11.002

A road map for the treatment of pediatric diffuse midline glioma

Cancer Cell. 2024 Jan 8;42(1):1-5. doi: 10.1016/j.ccell.2023.11.002. Epub 2023 Nov 30.

Authors

Carl Koschmann¹, Wajd N Al-Holou², Marta M Alonso³, Jamie Anastas⁴, Pratiti Bandopadhayay⁵, Tara Barron⁶, Oren Becher⁷, Rodrigo Cartaxo², Maria G Castro², Chan Chung⁸, Madison Clausen², Derek Dang², Robert Doherty², Ryan Duchatel⁹, Matthew Dun⁹, Mariella Filbin⁵, Andrea Franson², Stefanie Galban², Marc Garcia Moure³, Hugh Garton², Pruthvi Gowda⁵, Joana Graca Marques³, Cynthia Hawkins¹⁰, Allison Heath¹¹, Esther Hulleman¹², Sunjong Ji², Chris Jones¹³, Lindsay Kilburn¹⁴, Cassie Kline¹¹, Michael A Koldobskiy¹⁵, Daniel Lim¹⁶, Pedro R Lowenstein², Q Richard Lu¹⁷, Joanna Lum², Stephen Mack¹⁸, Suresh Magge², Bernard Marini², Donna Martin², Neena Marupudi², Dana Messinger², Rajen Mody², Meredith Morgan², Mateus Mota², Karin Muraszko², Sabine Mueller¹⁹, Siva Kumar Natarajan², Javad Nazarian²⁰, Michael Niculcea², Nicholas Nuechterlein²¹, Hideho Okada¹⁶, Valerie Opipari², Manjunath P Pai², Sharmistha Pal⁵, Erik Peterson², Timothy Phoenix¹⁷, John R Prensner², Matthew Pun², G Praveen Raju⁷, Zachary J Reitman²², Adam Resnick¹¹, David Rogawski⁶, Amanda Saratsis²³, Stefanie G Sbergio¹⁰, Mark Souweidane²⁴, James M Stafford²⁴, Theophilos Tzaridis²⁵, Sujatha Venkataraman²⁶, Orazio Vittorio²⁷, Jack Wadden², Daniel Wahl², Robert J Wechsler-Reya²⁸, Viveka Nand Yadav²⁹, Xu Zhang²⁸, Qiang Zhang², Sriram Venneti³⁰

Affiliations

¹ University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: ckoschma@med.umich.edu.
² University of Michigan, Ann Arbor, MI 48109, USA.
³ Clinica Universidad de Navarra, Navarra, Spain.
⁴ Baylor College of Medicine, Houston, TX 77030, USA.
⁵ Dana-Faber Cancer Institute, Boston, MA 02215, USA.
⁶ Stanford University, Stanford, CA 94305, USA.
⁷ Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁸ Daegu Gyeongbuk Institute of Science & Technology, Daegu, South Korea.
⁹ University of Newcastle, Callaghan, NSW 2308, Australia.
¹⁰ Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.
¹¹ Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
¹² Princess Maxima Center, 3584 CS Utrecht, the Netherlands.
¹³ Division of Molecular Pathology, Institute for Cancer Research, London SM2 5NG, UK.
¹⁴ Children's National, Washington, DC 20010, USA.
¹⁵ John Hopkins University, Baltimore, MD 21205, USA.
¹⁶ University of California, San Francisco, San Francisco, CA 94143, USA.
¹⁷ Cincinnati Children's Hospital Medical Center, and University of Cincinnati, Cincinnati, OH 45229, USA.
¹⁸ St. Jude, Memphis, TN 38105, USA.
¹⁹ University of California, San Francisco, San Francisco, CA 94143, USA; Parker Institute for Cancer Immunotherapy, University of Zurich, Zurich, Switzerland.
²⁰ Children's National, Washington, DC 20010, USA; University of Zurich, Zurich, Switzerland.
²¹ University of Michigan, Ann Arbor, MI 48109, USA; National Institutes of Health, Bethesda, MD, USA.
²² Duke Univesity, Durham, NC 27708, USA.
²³ Advocate Children's Hospital, Park Ridge, IL 60068, USA.
²⁴ Weill Cornell Medicine, New York Presbyterian and Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
²⁵ Herbert Irving Comprehensive Cancer Center and Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
²⁶ University of Colorado, Denver, CO 80204, USA.
²⁷ School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
²⁸ Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
²⁹ Children's Mercy, Kansas City, MO 64108, USA.
³⁰ University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: svenneti@med.umich.edu.

PMID: 38039965
DOI: 10.1016/j.ccell.2023.11.002

Abstract

Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biopsy
Brain / pathology
Brain Neoplasms* / genetics
Brain Neoplasms* / therapy
Child
Glioma* / diagnosis
Glioma* / genetics
Glioma* / therapy
Humans
Mutation

Abstract

Publication types

MeSH terms

Grants and funding