Spatial omics: An innovative frontier in aging research

Ying Chen; Shuhao Yang; Kaixu Yu; Jinjin Zhang; Meng Wu; Yongqiang Zheng; Yun Zhu; Jun Dai; Chunyan Wang; Xiaoran Zhu; Yun Dai; Yunhong Sun; Tong Wu; Shixuan Wang

doi:10.1016/j.arr.2023.102158

Spatial omics: An innovative frontier in aging research

Ageing Res Rev. 2024 Jan:93:102158. doi: 10.1016/j.arr.2023.102158. Epub 2023 Dec 4.

Authors

Ying Chen¹, Shuhao Yang¹, Kaixu Yu², Jinjin Zhang¹, Meng Wu¹, Yongqiang Zheng³, Yun Zhu⁴, Jun Dai¹, Chunyan Wang⁵, Xiaoran Zhu¹, Yun Dai¹, Yunhong Sun⁶, Tong Wu⁷, Shixuan Wang⁸

Affiliations

¹ Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China; Ministry of Education, Key Laboratory of Cancer Invasion and Metastasis, Wuhan, China.
² Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Centre, Sun Yat-sen University, Guangzhou, China.
⁴ Department of Internal Medicine, Southern Illinois University School of Medicine, 801 N. Rutledge, P.O. Box 19628, Springfield, IL 62702, USA.
⁵ College of Science & Engineering Jinan University, Guangzhou, China.
⁶ Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁷ Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China; Ministry of Education, Key Laboratory of Cancer Invasion and Metastasis, Wuhan, China. Electronic address: tongwu66@tjh.tjmu.edu.cn.
⁸ Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China; Ministry of Education, Key Laboratory of Cancer Invasion and Metastasis, Wuhan, China. Electronic address: sxwang@tjh.tjmu.edu.cn.

PMID: 38056503
DOI: 10.1016/j.arr.2023.102158

Abstract

Disentangling the impact of aging on health and disease has become critical as population aging progresses rapidly. Studying aging at the molecular level is complicated by the diverse aging profiles and dynamics. However, the examination of cellular states within aging tissues in situ is hampered by the lack of high-resolution spatial data. Emerging spatial omics technologies facilitate molecular and spatial analysis of tissues, providing direct access to precise information on various functional regions and serving as a favorable tool for unraveling the heterogeneity of aging. In this review, we summarize the recent advances in spatial omics application in multi-organ aging research, which has enhanced the understanding of aging mechanisms from multiple standpoints. We also discuss the main challenges in spatial omics research to date, the opportunities for further developing the technology, and the potential applications of spatial omics in aging and aging-related diseases.

Keywords: Aging; Aging research; Aging-related diseases; Spatial omics.

Publication types

Review

MeSH terms

Geroscience*
Humans