Identification and Management of Acute Neuromuscular Respiratory Failure in the ICU

Jennifer T W Krall; Akash Chakravartty; James B Caress; D Clark Files

doi:10.1016/j.chest.2023.09.009

Identification and Management of Acute Neuromuscular Respiratory Failure in the ICU

Chest. 2023 Dec;164(6):1454-1461. doi: 10.1016/j.chest.2023.09.009.

Authors

Jennifer T W Krall¹, Akash Chakravartty², James B Caress³, D Clark Files⁴

Affiliations

¹ Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC. Electronic address: jkrall@wakehealth.edu.
² Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
³ Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC.
⁴ Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Wake Forest University School of Medicine, Winston-Salem, NC.

PMID: 38070961
DOI: 10.1016/j.chest.2023.09.009

Abstract

Respiratory failure is a common and potentially life-threatening complication of neuromuscular diseases. Prompt recognition and accurate diagnosis of new or worsening chronic neuromuscular disease have important clinical management and prognostic implications. In this article, we present an approach to the acute presentation of undifferentiated neuromuscular respiratory failure in the ICU and guidance for determination and respiratory management of the underlying disorder.

Keywords: Guillain-Barré syndrome; ICU-acquired weakness; amyotrophic lateral sclerosis; myasthenia gravis; neuromuscular respiratory failure.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Intensive Care Units
Neuromuscular Diseases* / complications
Neuromuscular Diseases* / diagnosis
Neuromuscular Diseases* / therapy
Prognosis
Respiratory Insufficiency* / diagnosis
Respiratory Insufficiency* / etiology
Respiratory Insufficiency* / therapy