New strategy of personalized tissue regeneration: when autologous platelet concentrates encounter biomaterials

Sicong Ren; Hanchi Wang; Sijia Ma; Jing Zhou; Jingjie Zhai; Yuemeng Zhu; Sheng Chen; Siyu Chen; Kewen Jia; Wenzhou Xu; Yanmin Zhou

doi:10.3389/fbioe.2023.1297357

New strategy of personalized tissue regeneration: when autologous platelet concentrates encounter biomaterials

Front Bioeng Biotechnol. 2023 Nov 22:11:1297357. doi: 10.3389/fbioe.2023.1297357. eCollection 2023.

Authors

Sicong Ren^{1

2}, Hanchi Wang^{1

2}, Sijia Ma³, Jing Zhou², Jingjie Zhai¹, Yuemeng Zhu^{1

2}, Sheng Chen^{1

2}, Siyu Chen^{1

2}, Kewen Jia^{1

2}, Wenzhou Xu⁴, Yanmin Zhou¹

Affiliations

¹ Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
² Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
³ Yiwu Stomatology Hospital, Yiwu, Zhejiang, China.
⁴ Department of Periodontology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.

Abstract

Components in blood play an important role in wound healing and subsequent tissue regeneration processes. The fibrin matrix and various bioactive molecules work together to participate in this complex yet vital biological process. As a means of personalized medicine, autologous platelet concentrates have become an integral part of various tissue regeneration strategies. Here, we focus on how autologous platelet concentrates play a role in each stage of tissue healing, as well as how they work in conjunction with different types of biomaterials to participate in this process. In particular, we highlight the use of various biomaterials to protect, deliver and enhance these libraries of biomolecules, thereby overcoming the inherent disadvantages of autologous platelet concentrates and enabling them to function better in tissue regeneration.

Keywords: APC; PRP; biomaterials; regeneration; tissue.

Publication types

Review

Grants and funding

This research was funded by the National Natural Science Foundation of China (No. 82071152). The Science and Technology Project of Jilin Province Financial Department (JCSZ2021893-18), Science and Technology Project of Jilin Province (20220201121GX and 20210101271JC).