SIRT3 regulates mitochondrial function: A promising star target for cardiovascular disease therapy

Qin Zhang; Zhou Siyuan; Chang Xing; Liu Ruxiu

doi:10.1016/j.biopha.2023.116004

SIRT3 regulates mitochondrial function: A promising star target for cardiovascular disease therapy

Biomed Pharmacother. 2024 Jan:170:116004. doi: 10.1016/j.biopha.2023.116004. Epub 2023 Dec 11.

Authors

Qin Zhang¹, Zhou Siyuan¹, Chang Xing¹, Liu Ruxiu²

Affiliations

¹ Guang'anmen Hospital, Chinese Academy of traditional Chinese medicine, Beijing, China.
² Guang'anmen Hospital, Chinese Academy of traditional Chinese medicine, Beijing, China. Electronic address: Liuruxiu1@163.com.

PMID: 38086147
DOI: 10.1016/j.biopha.2023.116004

Abstract

Dysregulation of mitochondrial homeostasis is common to all types of cardiovascular diseases. SIRT3 regulates apoptosis and autophagy, material and energy metabolism, mitochondrial oxidative stress, inflammation, and fibrosis. As an important mediator and node in the network of mechanisms, SIRT3 is essential to many activities. This review explains how SIRT3 regulates mitochondrial homeostasis and the tricarboxylic acid cycle to treat common cardiovascular diseases. A novel description of the impact of lifestyle factors on SIRT3 expression from the angles of nutrition, exercise, and temperature is provided.

Keywords: Material energy metabolism; Mitochondrial dynamics; Mitophagy; Oxidative stress; SIRT3.

Publication types

Review

MeSH terms

Autophagy
Cardiovascular Diseases* / drug therapy
Cardiovascular Diseases* / metabolism
Energy Metabolism
Humans
Mitochondria / metabolism
Oxidative Stress
Sirtuin 3* / metabolism

Substances

Sirtuin 3
SIRT3 protein, human