Biogenic synthesis of dopamine/carboxymethyl cellulose/TiO2 nanoparticles using Psidium guajava leaf extract with enhanced antimicrobial and anticancer activities

Abstract

The green synthesis of metal oxide nanoparticles (NPs) has garnered considerable attention from researchers due to its utilization of eco-friendly solvents during synthesis and cost-effective approaches. This study focuses on the synthesis of titanium oxide (TiO₂) and dopamine (DA) carboxymethyl cellulose (CMC)-doped TiO₂ (DA/CMC/TiO₂) NP using Psidium guajava leaf extract, while also investigating the structural, optical, and morphological and biocidal potential of the prepared NPs. Significantly larger zones of inhibition were observed for DA/CMC/TiO₂ NPs compared to TiO₂ against various pathogens. Moreover, the MTT assay was carried out to evaluate the anticancer activity of the prepared samples against MG-63 cells, and the results revealed that DA/CMC/TiO₂ NPs exhibited significantly higher level of anticancer activity compared to TiO₂. The experimental results demonstrated that DA/CMC/TiO₂ NPs exhibited enhanced anticancer activity in a dose-dependent manner when compared to TiO₂ NPs.

Keywords: Anti- fungal activity; Anti-bacterial activity; Anti-cancer; CMC; Dopamine; Psidium guajava; TiO2.