Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease

Juan Huang; Lin Chen; Binbin Hu; Hui Wang; Xinyue Zhang; Xingfu Tian; Shu Wang; Wei Huang

doi:10.3389/fnagi.2023.1257799

Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease

Front Aging Neurosci. 2023 Dec 1:15:1257799. doi: 10.3389/fnagi.2023.1257799. eCollection 2023.

Authors

Juan Huang¹, Lin Chen¹, Binbin Hu¹, Hui Wang¹, Xinyue Zhang¹, Xingfu Tian¹, Shu Wang², Wei Huang¹

Affiliations

¹ Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, China.
² Department of Intensive Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China.

Abstract

Subjective cognitive complaints (SCCs), defined as cognitive decline reported by subjects or their informants, are common in the early stage of Parkinson's disease (PD). Previous studies have shown a significant association between SCCs and non-motor features as well as objective cognitive decline in PD patients. However, the discrepancy in SCC prevalence and SCC-related factors between patients with early PD and those with advanced PD remains poorly understood. We recruited a total of 114 and 69 early PD patients and advanced PD patients, respectively. Univariate and multivariate logistic regression analyses were performed for early PD and advanced PD patients. The prevalence of SCCs in the early PD and advanced PD groups was 60.5 and 68.1%, respectively. In the early PD group, the presence of SCCs in early PD participants was significantly associated with a higher nonmotor symptoms questionnaire (NMSQ) score (OR = 1.05, 95% CI = 1.00-1.10, p = 0.040). SCCs in the advanced PD group were related to lower attention scores (OR = 0.24, 95% CI = 0.05-0.90, p = 0.043) and lower visuospatial/executive abilities scores (OR = 0.18, 95% CI = 0.04-0.86, p = 0.032). The prevalence and SCC-related factors are distinct in early PD and advanced PD. These findings suggest that SCCs in PD patients with different disease statuses appear to have different related factors that may depend on different disease severities.

Keywords: advanced Parkinson's disease; attention; early Parkinson's disease; nonmotor symptoms; subjective cognitive complaints.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the General Project of Jiangxi Provincial Department of Education, 190070.