Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut

Shimpei Kawamoto; Eiji Hara

doi:10.1016/j.tcb.2023.12.004

Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut

Trends Cell Biol. 2024 Jan 13:S0962-8924(23)00254-4. doi: 10.1016/j.tcb.2023.12.004. Online ahead of print.

Authors

Shimpei Kawamoto¹, Eiji Hara²

Affiliations

¹ Department of Molecular Microbiology, Research Institute for Microbial Diseases (RIMD), Osaka University, Suita 565-0871, Japan. Electronic address: kshimpei@biken.osaka-u.ac.jp.
² Department of Molecular Microbiology, Research Institute for Microbial Diseases (RIMD), Osaka University, Suita 565-0871, Japan; Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan; Center for Infectious Diseases Education and Research, Osaka University, Suita 565-0871, Japan.

PMID: 38220548
DOI: 10.1016/j.tcb.2023.12.004

Abstract

Two phenomena, the accumulation of senescent cells and changes in the gut microbiota, are thought to contribute to the decline of biological functions and the development of diseases associated with aging. However, the relationship between these two phenomena and their effects on aging remains to be clarified. Recently, we have reported that gut bacteria induce cellular senescence in ileal germinal center (GC) B cells, resulting in decreased IgA production and diversity. This, in turn, leads to an imbalance in the gut microbiota. Thus, the crosstalk between the gut microbiota and cellular senescence via the host immune system may establish a vicious cycle and contribute to the disruption of gut homeostasis associated with aging.

Keywords: IgA; aging; cellular senescence; germinal center B cell; gut microbiota.

Publication types

Review