Hyperpolarized Gas Imaging in Lung Diseases: Functional and Artificial Intelligence Perspective

Ziwei Zhang; Haidong Li; Sa Xiao; Qian Zhou; Shiyuan Liu; Xin Zhou; Li Fan

doi:10.1016/j.acra.2024.01.014

Hyperpolarized Gas Imaging in Lung Diseases: Functional and Artificial Intelligence Perspective

Acad Radiol. 2024 Jan 16:S1076-6332(24)00014-X. doi: 10.1016/j.acra.2024.01.014. Online ahead of print.

Authors

Ziwei Zhang¹, Haidong Li², Sa Xiao², Qian Zhou³, Shiyuan Liu¹, Xin Zhou², Li Fan⁴

Affiliations

¹ Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, People's Republic of China (Z.Z., S.L., L.F.).
² State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovative Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China (H.L., S.X., Q.Z., X.Z.); University of Chinese Academy of Sciences, Beijing 100049, China (H.L., S.X., X.Z.).
³ State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovative Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China (H.L., S.X., Q.Z., X.Z.).
⁴ Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, People's Republic of China (Z.Z., S.L., L.F.). Electronic address: fanli0930@163.com.

PMID: 38233260
DOI: 10.1016/j.acra.2024.01.014

Abstract

Pathophysiologic changes in lung diseases are often accompanied by changes in ventilation and gas exchange. Comprehensive evaluation of lung function cannot be obtained through chest X-ray and computed tomography. Proton-based lung MRI is particularly challenging due to low proton density within the lung tissue. In this review, we discuss an emerging technology--hyperpolarized gas MRI with inhaled ¹²⁹Xe, which provides functional and microstructural information and has the potential as a clinical tool for detecting the early stage and progression of certain lung diseases. We review the hyperpolarized ¹²⁹Xe MRI studies in patients with a range of pulmonary diseases, including chronic obstructive pulmonary disease, asthma, cystic fibrosis, pulmonary hypertension, radiation-induced lung injury and interstitial lung disease, and the applications of artificial intelligence were reviewed as well.

Keywords: Artificial intelligence; Hyperpolarized gas imaging; Lung diseases; Magnetic resonance imaging; Xenon-129.

Publication types

Review