The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Yeo Jin Shin; Ki-Sun Kwon; Yousin Suh; Kwang-Pyo Lee

doi:10.3389/fmolb.2023.1308274

The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential

Front Mol Biosci. 2024 Jan 9:10:1308274. doi: 10.3389/fmolb.2023.1308274. eCollection 2023.

Authors

Yeo Jin Shin¹, Ki-Sun Kwon^{1

2

3}, Yousin Suh^{4

5}, Kwang-Pyo Lee^{1

2}

Affiliations

¹ Aging Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.
² Department of Bioscience, KRIBB School, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.
³ Aventi Inc., Daejeon, Republic of Korea.
⁴ Department of Obstetrics and Gynecology, Columbia University, New York, NY, United States.
⁵ Department of Genetics and Development, Columbia University, New York, NY, United States.

Abstract

Muscle aging is a complex physiological process that leads to the progressive decline in muscle mass and function, contributing to debilitating conditions in the elderly such as sarcopenia. In recent years, non-coding RNAs (ncRNAs) have been increasingly recognized as major regulators of muscle aging and related cellular processes. Here, we comprehensively review the emerging role of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the regulation of muscle aging. We also discuss how targeting these ncRNAs can be explored for the development of novel interventions to combat age-related muscle decline. The insights provided in this review offer a promising avenue for future research and therapeutic strategies aimed at improving muscle health during aging.

Keywords: aging; circRNA; lncRNA; miRNA; ncRNA; skeletal muscle.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the Bio & Medical Technology Development Program (2021R1C1C2009548 YJS and 2023R1A2C1004702 K-PL) of the National Research Foundation (NRF), the National Research Council of Science and Technology (NST) Aging Convergence Research Center (CRC22011-200), and KRIBB Research Initiative Program.