FAPI PET Missed Widespread Bone Marrow Metastases From Follicular Thyroid Cancer That Were Detected by FDG PET

Clin Nucl Med. 2024 Mar 1;49(3):e125-e126. doi: 10.1097/RLU.0000000000005031. Epub 2024 Jan 24.

Abstract

A 62-year-old woman with follicular thyroid cancer who had received total thyroidectomy and multiple rounds of radioactive iodine therapy underwent both 18 F-FDG and 18 F-FAPI PET/CT. 18 F-FAPI PET failed to reveal widespread bone marrow metastases that were clear visualized on 18 F-FDG PET. This case highlights that FAPI PET may not be used to describe bone metastases in detail in follicular thyroid cancer patients, as it is not a sensitive method to detect bone marrow metastases.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Follicular*
  • Bone Marrow Neoplasms* / diagnostic imaging
  • Female
  • Fluorodeoxyglucose F18
  • Gallium Radioisotopes
  • Humans
  • Iodine Radioisotopes / therapeutic use
  • Middle Aged
  • Positron Emission Tomography Computed Tomography
  • Thyroid Neoplasms* / diagnostic imaging

Substances

  • Fluorodeoxyglucose F18
  • Iodine Radioisotopes
  • Gallium Radioisotopes

Supplementary concepts

  • Thyroid cancer, follicular