Unraveling the Tcrb interactome

Noah Ollikainen; Ranjan Sen

doi:10.1084/jem.20232265

Unraveling the Tcrb interactome

J Exp Med. 2024 Feb 5;221(2):e20232265. doi: 10.1084/jem.20232265. Epub 2024 Jan 29.

Authors

Noah Ollikainen¹, Ranjan Sen¹

Affiliation

¹ Laboratory of Molecular Biology and Immunology, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.

PMID: 38284995
PMCID: PMC10824074 (available on 2024-07-29)
DOI: 10.1084/jem.20232265

Abstract

In this issue of JEM, Allyn et al. (https://doi.org/10.1084/jem.20230985) provide mechanistic insights into the nuclear organization of the Tcrb locus that permits long-range genomic rearrangements.

MeSH terms

Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor*
Receptors, Antigen, T-Cell, alpha-beta* / genetics

Substances

Receptors, Antigen, T-Cell, alpha-beta

Grants and funding

AG/NIA NIH HHS/United States