Chronic rhinosinusitis （CRS） is a chronic inflammatory disease of the sinus mucosa, and the pathogenesis of CRS has not been fully elucidated, and the impact of dysbiosis of the microbiome in the nasal cavity and even in the gut on the pathogenesis of CRS remains controversial. Next-generation sequencing technology, a culture-independent high-throughput sequencing method, contributes to a comprehensive understanding of the CRS microbiome. This article reviews the progress of research on the relevance of bacteria and other microorganisms to CRS and the microbial characteristics of the sinus and intestinal tract of patients with CRS, introduces next-generation sequencing technologies for the study of the CRS microbiome, and discusses the therapeutic prospects of CRS and the possibility of probiotic therapy.
摘要: 慢性鼻窦炎（CRS）是一种鼻窦黏膜慢性炎性疾病，目前CRS的发病机制尚未完全阐明，鼻腔乃至肠道内的微生物组失调对CRS发病机制的影响，仍存有争议。新一代测序技术是一种不依赖于培养的高通量测序方法，有助于人们对CRS微生物组的综合性认识。本文综述了细菌和其他微生物与CRS的相关性以及CRS患者鼻窦、肠道微生物特点这一领域的研究进展，介绍了新一代测序技术用于CRS微生物组的研究成果，并探讨了微生物群疗法应用于CRS的治疗前景和可能性，以期为临床医师和相关领域科研工作者明确该病的发病机制及有效治疗方案提供参考。.
Keywords: next-generation sequencing technology; chronic sinusitis; microorganisms.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.