In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections

Noemí Balà; Alejandro Aranda; Pau Teixidó; Carlota Molhoek; Inés Moreno-Jiménez; Germán Febas; Júlia López-Guimet; Adam Groothuis; Elazer Reuven Edelman; Mercedes Balcells; Salvador Borrós; Jordi Martorell; Vicente Riambau

doi:10.1016/j.jacbts.2023.08.002

In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections

JACC Basic Transl Sci. 2023 Oct 11;9(1):65-77. doi: 10.1016/j.jacbts.2023.08.002. eCollection 2024 Jan.

Authors

Noemí Balà^{1

2}, Alejandro Aranda^{1

2}, Pau Teixidó^{1

2}, Carlota Molhoek^{1

2}, Inés Moreno-Jiménez², Germán Febas², Júlia López-Guimet², Adam Groothuis³, Elazer Reuven Edelman³, Mercedes Balcells^{1

3}, Salvador Borrós^{1

2}, Jordi Martorell^{1

2}, Vicente Riambau^{2

4}

Affiliations

¹ IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain.
² Aortyx SL, Teia, Spain.
³ Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
⁴ Vascular Surgery Department, Hospital Clínic de Barcelona, Barcelona, Spain.

Abstract

Endovascular repair of aortic dissection still presents significant limitations. Preserving the mechanical and biological properties set by the aortic microstructure is critical to the success of implantable grafts. In this paper, we present the performance of an adhesive bioresorbable patch designed to cover the entry tear of aortic dissections. We demonstrate the power of using a biomimetic scaffold in a vascular environment.

Keywords: aorta; biomaterials; dissection.