Viral pancreatitis: research advances and mechanisms

Xianqiang Yu; Minchao Wang; Qingming Kong

doi:10.3389/fmicb.2023.1326837

Viral pancreatitis: research advances and mechanisms

Front Microbiol. 2024 Feb 14:14:1326837. doi: 10.3389/fmicb.2023.1326837. eCollection 2023.

Authors

Xianqiang Yu^#¹, Minchao Wang^#², Qingming Kong^{3

4}

Affiliations

¹ Medical School, Qingdao University, Qingdao, China.
² Lishui Second People's Hospital Affiliated to Wenzhou Medical University, Lishui, China.
³ School of Basic Medicine and Forensics, Key Laboratory of Bio-tech Vaccine of Zhejiang Province, Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China.
⁴ Key Laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang province, School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou, China.

^# Contributed equally.

Abstract

Acute pancreatitis is caused by trypsinogen activation in acinar cells caused by various injury forms (gallstone, high triglycerides, alcohol, etc.). Viral pancreatitis is a clinically rare disease type, which is easily neglected by clinicians and causes serious adverse consequences. Viral pancreatitis involves the entry of viruses into pancreatic cells, triggering inflammation, immune response activation, and enzymatic autodigestion, leading to tissue damage and potential complications. At present, there are few available reports on viral pancreatitis, most of which are case reports. This review brings attention to clinicians by describing the incidence of viral pancreatitis to enhance clinical understanding and patient care.

Keywords: acinar cells; acute pancreatitis; angiotensin-converting enzyme; viral pancreatitis; virus.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents under grant number WJW2021002; Science Foundation of National Health Commission of the PRC under grant number WJW-ZJ-2203; and the Key R&D projects of Zhejiang province under grant number 2022C03109.