The mitochondrial antiviral-signaling protein (MAVS), a core adaptor protein in the retinoic-acid-inducible gene-I-like receptors (RLRs)-MAVS pathway, has been demonstrated to play an important role in antiviral immune response and tumor immunology. Previous studies revealed that ubiquitylation is a key mechanism in the regulation of the RLRs-MAVS axis and immune response. Multiple E3 ubiquitin ligases and deubiquitinating enzymes control MAVS ubiquitylation and changes in MAVS function. In this review, we summarize the biological function of ubiquitylation in MAVS-related signaling and provide new insight into immunotherapy approaches that target MAVS.
Keywords: HECT E3 ligase; MAVS; RING-finger type E3 ligase; SUMO E3 ligase; SUMOylation; U-box type E3 ligase; de-ubiquitinase; ubiquitylation; virus-derived proteins function as E3 ligase.
© 2024 The Author(s). Published by IMR Press.