UCP1 and CKB are parallel players in BAT

Meng Dong; Ziyu Cheng; Wanzhu Jin

doi:10.1016/j.cmet.2024.01.016

UCP1 and CKB are parallel players in BAT

Cell Metab. 2024 Mar 5;36(3):459-460. doi: 10.1016/j.cmet.2024.01.016.

Authors

Meng Dong¹, Ziyu Cheng², Wanzhu Jin³

Affiliations

¹ Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 1 West Beichen Road No. 5, Chaoyang District, Beijing 100101, China.
² Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 1 West Beichen Road No. 5, Chaoyang District, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
³ Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 1 West Beichen Road No. 5, Chaoyang District, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address: jinw@ioz.ac.cn.

PMID: 38447527
DOI: 10.1016/j.cmet.2024.01.016

Abstract

It is generally believed that the contributions of the UCP1-independent thermogenic pathways are secondary to UCP1-mediated thermogenesis in BAT. Now, Rahbani et al. demonstrate in vivo that adaptive thermogenesis in brown adipose tissue is regulated by UCP1 and CKB in parallel.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adipose Tissue, Brown*
Thermogenesis*