SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases

Yi-Zhu Jiang; Xin-Ran Huang; Jing Chang; Yong Zhou; Xiao-Ting Huang

doi:10.1016/j.labinv.2024.102044

SIRT1: An Intermediator of Key Pathways Regulating Pulmonary Diseases

Lab Invest. 2024 Mar 5;104(5):102044. doi: 10.1016/j.labinv.2024.102044. Online ahead of print.

Authors

Yi-Zhu Jiang¹, Xin-Ran Huang¹, Jing Chang¹, Yong Zhou², Xiao-Ting Huang³

Affiliations

¹ Xiangya Nursing School, Central South University, Changsha, China; Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
² Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
³ Xiangya Nursing School, Central South University, Changsha, China. Electronic address: huangxiaoting@csu.edu.cn.

PMID: 38452903
DOI: 10.1016/j.labinv.2024.102044

Abstract

Silent information regulator type-1 (SIRT1), a nicotinamide adenine dinucleotide⁺-dependent deacetylase, is a member of the sirtuins family and has unique protein deacetylase activity. SIRT1 participates in physiological as well as pathophysiological processes by targeting a wide range of protein substrates and signalings. In this review, we described the latest progress of SIRT1 in pulmonary diseases. We have introduced the basic information and summarized the prominent role of SIRT1 in several lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung cancer, and aging-related diseases.

Keywords: SIRT1; inflammation; oxidative stress; pulmonary disease; signaling pathway.

Publication types

Review