Protein phosphatase 2A modulation and connection with miRNAs and natural products

Ya-Ting Chuang; Ching-Yu Yen; Jen-Yang Tang; Fang-Rong Chang; Yi-Hong Tsai; Kuo-Chuan Wu; Tsu-Ming Chien; Hsueh-Wei Chang

doi:10.1002/tox.24199

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Environ Toxicol. 2024 Mar 16. doi: 10.1002/tox.24199. Online ahead of print.

Authors

Ya-Ting Chuang¹, Ching-Yu Yen^{2

3}, Jen-Yang Tang^{4

5}, Fang-Rong Chang⁶, Yi-Hong Tsai⁷, Kuo-Chuan Wu⁸, Tsu-Ming Chien⁹, Hsueh-Wei Chang^{1

10

11}

Affiliations

¹ Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
² School of Dentistry, Taipei Medical University, Taipei, Taiwan.
³ Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
⁴ School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁵ Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁷ Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung, Taiwan.
⁸ Department of Computer Science and Information Engineering, National Pingtung University, Pingtung, Taiwan.
⁹ Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
¹⁰ Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
¹¹ Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

PMID: 38491812
DOI: 10.1002/tox.24199

Abstract

Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part of the PP2A family has been investigated. This review focuses on the PP2A-modulating effects of natural products and miRNAs' interactions with potential PP2A targets in cancer and non-cancer cells. PP2A-modulating natural products and miRNAs were retrieved through a literature search. Utilizing the miRDB database, potential PP2A targets of these PP2A-modulating miRNAs for the whole set (17 members) of the PP2A family were retrieved. Finally, PP2A-modulating natural products and miRNAs were linked via a literature search. This review provides systemic directions for assessing natural products and miRNAs relating to the PP2A-modulating functions in cancer and disease treatments.

Keywords: PP2A; miRDB; miRNA; natural products.

Abstract

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