A Comprehensive Examination of Heterocyclic Scaffold Chemistry for Antitubercular Activity

Chem Biodivers. 2024 May;21(5):e202400067. doi: 10.1002/cbdv.202400067. Epub 2024 Apr 25.

Abstract

Tuberculosis is a communicable disease which affects humans particularly the lungs and is transmitted mainly through air. Despite two decades of intensive research aimed at understanding and combating tuberculosis, persistent biological uncertainties continue to hinder progress. Nowadays, heterocyclic compounds have proven themselves in effective treatment of tuberculosis because of their wide range of biological and pharmacological activities. Antituberculosis or antimycobacterial agents encompass a broad array of compounds utilized singly or in conjunction to combat Mycobacterium infections, spanning from tuberculosis to leprosy. Here, we summarize the synthesis of various heterocyclic compounds which includes the greener synthetic route as well as use of nano compounds as catalyst along with their anti TB activities.

Keywords: Academics; Antitubercular Activities; Heterocycle Scaffolds; Pharmaceutical Sector and Tuberculosis Research.

Publication types

  • Review

MeSH terms

  • Antitubercular Agents* / chemical synthesis
  • Antitubercular Agents* / chemistry
  • Antitubercular Agents* / pharmacology
  • Heterocyclic Compounds* / chemical synthesis
  • Heterocyclic Compounds* / chemistry
  • Heterocyclic Compounds* / pharmacology
  • Humans
  • Microbial Sensitivity Tests*
  • Molecular Structure
  • Mycobacterium tuberculosis* / drug effects
  • Tuberculosis / drug therapy