p53: A tale of complexity and context

Moshe Oren; Carol Prives

doi:10.1016/j.cell.2024.02.043

p53: A tale of complexity and context

Cell. 2024 Mar 28;187(7):1569-1573. doi: 10.1016/j.cell.2024.02.043.

Authors

Moshe Oren¹, Carol Prives²

Affiliations

¹ Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: moshe.oren@weizmann.ac.il.
² Department of Biological Sciences, Columbia University, New York, NY, USA. Electronic address: clp3@columbia.edu.

PMID: 38552605
DOI: 10.1016/j.cell.2024.02.043

Abstract

The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein.

MeSH terms

Humans
Mutation
Neoplasms* / drug therapy
Neoplasms* / genetics
Tumor Suppressor Protein p53* / genetics
Tumor Suppressor Protein p53* / metabolism

Substances

Tumor Suppressor Protein p53