Evidence of a preferential inactivation of the paternally derived X chromosome in a 46,XX true hermaphrodite

Hum Genet. 1985;69(1):91-3. doi: 10.1007/BF00295538.

Abstract

The pattern of inheritance of several X polymorphic markers is studied in the pedigree of a 46,XX true hermaphrodite. The results of the Xga, 12E7, and G6PD segregation analysis favour the hypothesis of a preferential inactivation of the paternally derived X chromosome.

Publication types

  • Case Reports

MeSH terms

  • Blood Group Antigens / genetics
  • Disorders of Sex Development / genetics*
  • Dosage Compensation, Genetic*
  • Female
  • Genetic Markers*
  • Glucosephosphate Dehydrogenase / genetics
  • H-Y Antigen / genetics
  • HLA Antigens / genetics
  • Humans
  • Karyotyping
  • Pedigree
  • Polymorphism, Genetic

Substances

  • Blood Group Antigens
  • Genetic Markers
  • H-Y Antigen
  • HLA Antigens
  • Glucosephosphate Dehydrogenase