A Systematic Review of Female Participation in Randomized Controlled Trials of Post-Stroke Upper Extremity Rehabilitation in Low- to Middle-Income Countries and High-Income Countries and Regions

Sarvenaz Mehrabi; Lindsay Cameron; Andrew Bowman; Jamie L Fleet; Janice Eng; Mark Theodore Bayley; Robert Teasell

doi:10.1159/000538610

A Systematic Review of Female Participation in Randomized Controlled Trials of Post-Stroke Upper Extremity Rehabilitation in Low- to Middle-Income Countries and High-Income Countries and Regions

Cerebrovasc Dis. 2024 Apr 6:1-10. doi: 10.1159/000538610. Online ahead of print.

Authors

Sarvenaz Mehrabi¹, Lindsay Cameron², Andrew Bowman², Jamie L Fleet^{2

3

4}, Janice Eng^{5

6}, Mark Theodore Bayley^{7

8}, Robert Teasell^{2

3

4}

Affiliations

¹ Parkwood Institute Research, Parkwood Institute, London, Ontario, Canada, sarvenazmehrabi@gmail.com.
² Parkwood Institute Research, Parkwood Institute, London, Ontario, Canada.
³ St. Joseph's Health Care London, London, Ontario, Canada.
⁴ Physical Medicine and Rehabilitation, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
⁵ Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
⁶ Rehabilitation Research Program, Centre for Aging SMART, Vancouver, British Columbia, Canada.
⁷ KITE Research Institute, UHN-Toronto Rehabilitation institute, Toronto, Ontario, Canada.
⁸ Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

PMID: 38583429
DOI: 10.1159/000538610

Abstract

Introduction: Female participation is lower than males in both acute stroke and stroke rehabilitation trials. However, less is known about how female participation differs across countries and regions. This study aimed to assess the percentage of female participants in randomized controlled trials (RCTs) of post-stroke rehabilitation of upper extremity (UE) motor disorders in low-middle-income (LMICs) and high-income countries (HICs) as well as different high-income world regions.

Methods: CINAHL, Embase, PubMed, Scopus, and Web of Science were searched from 1960 to April 1, 2021. Studies were eligible for inclusion if they (1) were RCTs or crossovers published in English; (2) ≥50% of participants were diagnosed with stroke; 3) included adults ≥18 years old; and (4) applied an intervention to the hemiparetic UE as the primary objective of the study. Countries were divided into HICs and LMICs based on their growth national incomes. The HICs were further divided into the three high-income regions of North America, Europe, and Asia and Oceania. Data analysis was performed using SPSS and RStudio v.4.3.1.

Results: A total of 1,276 RCTs met inclusion criteria. Of them, 298 RCTs were in LMICs and 978 were in HICs. The percentage of female participants was significantly higher in HICs (39.5%) than LMICs (36.9%). Comparing high-income regions, there was a significant difference in the overall female percentages in favor of RCTs in Europe compared to LMICs but not North America or Asia and Oceania. There was no significant change in the percentage of female participants in all countries and regions over the last 2 decades, with no differences in trends between the groups.

Conclusions: Sufficient female representation in clinical trials is required for the generalizability of results. Despite differences in overall percentage of female participation between countries and regions, females have been underrepresented in both HICs and LMICs with no considerable change over 2 decades.

Keywords: Country income; Female; Regional differences; Sex differences; Stroke rehabilitation; Upper extremity.

Publication types

Systematic Review