Exploring the molecular mechanisms between lymphoma and myelofibrosis

Jun-Nuan Wang; Yan Li

doi:10.62347/NWJO7078

Exploring the molecular mechanisms between lymphoma and myelofibrosis

Am J Transl Res. 2024 Mar 15;16(3):730-737. doi: 10.62347/NWJO7078. eCollection 2024.

Authors

Jun-Nuan Wang^{1

2}, Yan Li²

Affiliations

¹ Hebei Medical University Shijiazhuang, Hebei, The People's Republic of China.
² Department of Hematology, Hebei General Hospital Shijiazhuang, Hebei, The People's Republic of China.

Abstract

Lymphoma is a heterogeneous malignant tumor with an increasing annual incidence. As the lymphoma progresses, bone marrow (BM) invasion gradually appears. Myelofibrosis (MF) can accompany a variety of hematological malignancies, including lymphoma, and multiple myeloma. The prognosis of lymphoma patients with myelofibrosis is poor, and a fundamental reason is that there are few studies on the correlation and pathogenesis of the two diseases. In this review, we examine the potential pathogenesis and the correlation of the two diseases.

Keywords: JAK-STAT signaling pathway; Lymphoma; myelofibrosis; tumor microenvironment.

Publication types

Review