Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies

Kayvan Mehdipour Chari; Seyed Ehsan Enderami; Reyhaneh Nassiri Mansour; Elham Hasanzadeh; Javad Amini Mahabadi; Mohamadfoad Abazari; Peyman Asadi; Atefeh Hojjat

doi:10.1016/j.reth.2024.02.011

Applications of blood plasma derivatives for cutaneous wound healing: A mini-review of clinical studies

Regen Ther. 2024 Apr 6:27:251-258. doi: 10.1016/j.reth.2024.02.011. eCollection 2024 Dec.

Authors

Kayvan Mehdipour Chari¹, Seyed Ehsan Enderami², Reyhaneh Nassiri Mansour^{2

3}, Elham Hasanzadeh³, Javad Amini Mahabadi⁴, Mohamadfoad Abazari^{5

6}, Peyman Asadi⁷, Atefeh Hojjat¹

Affiliations

¹ Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
² Immunogenetics Research Center, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
³ Department of Tissue Engineering & Regenerative Medicine, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Anatomical Research Center, Kashan University of Medical Sciences, Kashan, Iran.
⁵ Division of Medical Sciences, Island Medical Program, University of British Columbia, Victoria, BC, Canada.
⁶ Department of Biology, Centre for Biomedical Research, University of Victoria, Victoria, Canada.
⁷ Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

Skin injuries are a global healthcare problem. Chronic ulcers do not heal in a timely fashion, so it is essential to help the body with skin repair. There are some treatments that have been applied to chronic ulcers. One of these treatments is growth factor (GF) therapy. Platelet-rich plasma (PRP) and Platelet-poor plasma (PPP) are two types of plasma derivatives containing many GFs important for wound healing. Several works have reported their application in wound healing and tissue regeneration. The use of autologous PRP is now an adequate alternative in regenerative medicine. It was also demonstrated that PPP is a hemostatic agent for wounds. This review has studied the latest clinical studies, which have applied PRP and PPP to patients with chronic wounds.

Keywords: Chronic wounds; Clinical study; Platelet-poorplasma; Platelet-rich plasma; Skin.

Publication types

Review