Phytochemical profile and hepatoprotective potentiality of Phyllanthus genus: a review

H Pratima; Anita Shiraguppi; Priyadarshini Joojagar; Kamal Shah; Sudharani S Cheeraladinni; P Shivakumar Singh; Suresh Kumar Mendem; Nagendra Singh Chauhan

doi:10.1093/jpp/rgae040

Phytochemical profile and hepatoprotective potentiality of Phyllanthus genus: a review

J Pharm Pharmacol. 2024 Apr 20:rgae040. doi: 10.1093/jpp/rgae040. Online ahead of print.

Authors

H Pratima¹, Anita Shiraguppi¹, Priyadarshini Joojagar¹, Kamal Shah², Sudharani S Cheeraladinni¹, P Shivakumar Singh³, Suresh Kumar Mendem⁴, Nagendra Singh Chauhan⁵

Affiliations

¹ Department of Post-Graduate Studies and Research in Botany, Akkamahadevi Women's University, Vijayapur 568101, Karnataka, India.
² Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura 281406, India.
³ Department of Botany, Palamuru University, Mahabubnagar 509001, Telangana, India.
⁴ Department of Post-Graduate Studies and Research in Microbiology, Gulbarga University, Kalaburagi 585106, Karnataka, India.
⁵ Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur 490008, India.

PMID: 38642916
DOI: 10.1093/jpp/rgae040

Abstract

The Phyllanthus genus is very important plant traded as a raw herbal medicine in India. Commonly known as 'Bhumyamalaki' (Phyllanthus species) has been used for the prevention and treatment of jaundice. Phyllanthus is rich in diversity of bioactive compounds such as lignans, alkaloids, terpenoids, flavonoids, and tannins. Among some metabolites such as phyllanthin, hypophyllanthin, 8, 9-epoxy brevifolin, brevifolin, quercetin, gallic acid, elagic acid, and brevifolin carboxylate have been shown to have hepatoprotective and antioxidant activity found in this genus. The basic objective of this review was to overview the hepatoprotective activity based on the other available data from various plants of the Phyllanthus species including Phyllanthus amarus, Phyllanhtus urinaria, Phyllanthus fraternus, Phyllanthus maderaspatenis, Phyllanthus simplex, Phyllanthus emblica, Phyllanthus debillis, Phyllanthus tenellus, Phyllanthus polyphyllus, Phyllanthus reticulates, Phyllanthus indofischerii, Phyllanthus acidus, Phyllanthus niruri, Phyllanthus rheedii, Phyllanthus kozhikodianus, and Phyllanthus longiflorus. These species studied had considerable hepatoprotective potential. The secondary data, each in vitro and in vivo studies confirm the capacity of Phyllanthus species used as a remedy for jaundice or liver disease in addition to having antioxidants. Furthermore, it could be concluded that herbal drugs have the least side effects and are taken into considered safe for human health, they are able to substantially alternative synthetic drugs in the future.

Keywords: Phyllanthus; antioxidants; hepatoprotective; phytochemicals.

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