Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery

Qian Xiao; Lingling Shang; Yang Peng; Ludan Zhang; Yanze Wei; Decai Zhao; Yasong Zhao; Jiawei Wan; Yuguang Wang; Dan Wang

doi:10.1002/smtd.202301664

Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery

Small Methods. 2024 Apr 28:e2301664. doi: 10.1002/smtd.202301664. Online ahead of print.

Authors

Qian Xiao^{1

2

3}, Lingling Shang^{1

2

3}, Yang Peng⁴, Ludan Zhang⁴, Yanze Wei^{1

2}, Decai Zhao^{1

2}, Yasong Zhao^{1

2}, Jiawei Wan^{1

2

3}, Yuguang Wang⁴, Dan Wang^{1

2

3}

Affiliations

¹ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
² Key Laboratory of Biopharmaceutical Preparation and Delivery, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
³ University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, P. R. China.
⁴ Center of Digital Dentistry/Department of Prosthodontics, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of Engineering and Technology for Computerized Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

PMID: 38678518
DOI: 10.1002/smtd.202301664

Abstract

Multifunctional drug delivery systems (DDS) are in high demand for effectively targeting specific cells, necessitating excellent biocompatibility, precise release mechanisms, and sustained release capabilities. The hollow multishelled structure (HoMS) presents a promising solution, integrating structural and compositional design for efficient DDS development amidst complex cellular environments. Herein, starting from a Fe-based metal-organic framework (MOF), amorphous coordination polymers (CP) composited HoMS with controlled shell numbers are fabricated by balancing the rate of MOF decomposition and shell formation. Fe-CP HoMS loaded with DOX is utilized for synergistic chemotherapy and chemodynamic therapy, offering excellent responsive drug release capability (excellent pH-triggered drug release 82% within 72 h at pH 5.0 solution with doxorubicin (DOX) loading capacity of 284 mg g^-1). In addition to its potent chemotherapy attributes, Fe-CP-HoMS possesses chemodynamic therapy potential by continuously catalyzing H₂O₂ to generate ·OH species within cancer cells, thus effectively inhibiting cancer cell proliferation. DOX@3S-Fe-CP-HoMS, at a concentration of 12.5 µg mL^-1, demonstrates significant inhibitory effects on cancer cells while maintaining minimal cytotoxicity toward normal cells. It is envisioned that CP-HoMS could serve as an effective and biocompatible platform for the advancement of intelligent drug delivery systems in the realm of cancer therapy.

Keywords: coordination polymer; drug delivery systems; hollow multishelled structure; metal‐organic framework template; multifunctional material.

Abstract

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