Alkaloid constituents from Anacyclus pyrethrum

Hui Chen; Haji Akber Aisa

doi:10.1016/j.phytochem.2024.114116

Alkaloid constituents from Anacyclus pyrethrum

Phytochemistry. 2024 Apr 29:114116. doi: 10.1016/j.phytochem.2024.114116. Online ahead of print.

Authors

Hui Chen¹, Haji Akber Aisa²

Affiliations

¹ State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, South Beijing Road 40-1, Urumqi, China; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 10004, P.R. China.
² State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, South Beijing Road 40-1, Urumqi, China; College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China. Electronic address: haji@ms.xjb.ac.cn.

PMID: 38692343
DOI: 10.1016/j.phytochem.2024.114116

Abstract

Twelve undescribed alkaloids, including eight pyrrolo[3,2-g]isoquinoline alkaloids (+)/(-)-anacyquinoline A (1a/1b), (±)-anacyquinoline B (2), (+)/(-)-anacyquinoline C (3a/3b), (±)-anacyquinoline D (4), (±)-anacyquinoline E (5), and (±)-anacyquinoline F (6), together with four pyrrolo[2,3-g]quinoline alkaloids (+)/(-)-anacyquinoline G (7a/7b), (±)-anacyquinoline H (8), and (±)-anacyquinoline I (9), were isolated from the root of Anacyclus pyrethrum (L.) DC. Their structures were determined via spectroscopic analyses (UV, IR, NMR), HRESIMS, quantum chemical calculations of ECD and NMR data, and single-crystal X-ray diffraction analysis (Cu Kα). In bioassay, (+)/(-)-anacyquinoline G (7a/7b), and (±)-anacyquinoline H (8) showed inhibition on NO production with IC₅₀ values of 41.4, 44.1, and 31.4 μM, respectively.

Keywords: Alkaloids; Anacyclus pyrethrum; Anti-inflammatory; Asteraceae.