Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer

Svetlana A Katkova; Alexander S Bunev; Rovshan E Gasanov; Dmitry A Khochenkov; Andrey V Kulsha; Oleg A Ivashkevich; Tatiyana V Serebryanskaya; Mikhail A Kinzhalov

doi:10.1002/chem.202401199

Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer

Chemistry. 2024 May 17;30(28):e202401199. doi: 10.1002/chem.202401199. Epub 2024 May 2.

Authors

Svetlana A Katkova¹, Alexander S Bunev², Rovshan E Gasanov², Dmitry A Khochenkov^{2

3}, Andrey V Kulsha⁴, Oleg A Ivashkevich⁵, Tatiyana V Serebryanskaya⁵, Mikhail A Kinzhalov¹

Affiliations

¹ Saint Petersburg State University, 7/9 Universitetskaya Nab., 199034, St. Petersburg, Russian Federation.
² Medicinal Chemistry Center, Togliatti State University, Belorusskaya 14, 445020, Togliatti, Russian Federation.
³ Blokhin National Medical Research Center of Oncology, Kashirskoe Shosse 24, 115478, Moscow, Russian Federation.
⁴ Department of Chemistry, Belarusian State University, Leningradskaya 14, 220006, Minsk, Belarus.
⁵ Research Institute for Physical Chemical Problems, Belarusian State University, Leningradskaya 14, 220006, Minsk, Belarus.

PMID: 38695718
DOI: 10.1002/chem.202401199

Abstract

Invited for the cover of this issue are Tatiyana Serebryanskaya, Mikhail Kinzhalov and co-workers at St. Petersburg State University, the Research Institute for Physical Chemical Problems, Belarusian State University, Togliatti State University and Blokhin National Medical Research Center of Oncology. The image depicts the shield of Pallas Athena with the structure of a palladium carbene complex that protects against triple-negative breast cancer. Read the full text of the article at 10.1002/chem.202400101.

MeSH terms

Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Cell Line, Tumor
Cell Proliferation* / drug effects
Coordination Complexes* / chemistry
Coordination Complexes* / pharmacology
Female
Humans
Methane / analogs & derivatives
Methane / chemistry
Methane / pharmacology
Palladium / chemistry
Triple Negative Breast Neoplasms* / drug therapy
Triple Negative Breast Neoplasms* / pathology

Substances

carbene