Exchangeable leaders of collectively migrating glioma abuse N-cadherin trafficking

J Cell Biol. 2024 Jun 3;223(6):e202404129. doi: 10.1083/jcb.202404129. Epub 2024 May 3.

Abstract

Collectively migrating cells consist of leaders and followers with different features. In this issue, Kim et al. (https://doi.org/10.1083/jcb.202401057) characterize the leader and follower cells in collective glioma migration and uncover important roles of YAP1/TAZ-mediated regulation of N-cadherin in the leader cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism
  • Antigens, CD / genetics
  • Antigens, CD / metabolism
  • Cadherins* / genetics
  • Cadherins* / metabolism
  • Cell Movement
  • Glioma* / genetics
  • Glioma* / metabolism
  • Glioma* / pathology
  • Humans
  • Protein Transport
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • YAP-Signaling Proteins / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Antigens, CD
  • Cadherins
  • Transcription Factors
  • YAP-Signaling Proteins
  • YAP1 protein, human