Metabolic reprogramming and interventions in angiogenesis

Yun Liu; Zifang Wu; Yikun Li; Yating Chen; Xuan Zhao; Miaomiao Wu; Yaoyao Xia

doi:10.1016/j.jare.2024.05.001

Metabolic reprogramming and interventions in angiogenesis

J Adv Res. 2024 May 3:S2090-1232(24)00178-4. doi: 10.1016/j.jare.2024.05.001. Online ahead of print.

Authors

Yun Liu¹, Zifang Wu², Yikun Li³, Yating Chen¹, Xuan Zhao⁴, Miaomiao Wu⁵, Yaoyao Xia⁶

Affiliations

¹ College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
² College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
³ College of Animal Science and Technology, Southwest University, Chongqing 400715, China; College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China.
⁴ College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: zhaoxuann@swu.edu.cn.
⁵ Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address: miaomiaowu0316@hunau.edu.cn.
⁶ College of Animal Science and Technology, Southwest University, Chongqing 400715, China. Electronic address: yaoyaoxia20230750@swu.edu.cn.

PMID: 38704087
DOI: 10.1016/j.jare.2024.05.001

Abstract

Background: Endothelial cell (EC) metabolism plays a crucial role in the process of angiogenesis. Intrinsic metabolic events such as glycolysis, fatty acid oxidation, and glutamine metabolism, support secure vascular migration and proliferation, energy and biomass production, as well as redox homeostasis maintenance during vessel formation. Nevertheless, perturbation of EC metabolism instigates vascular dysregulation-associated diseases, especially cancer.

Aim of review: In this review, we aim to discuss the metabolic regulation of angiogenesis by EC metabolites and metabolic enzymes, as well as prospect the possible therapeutic opportunities and strategies targeting EC metabolism.

Key scientific concepts of review: In this work, we discuss various aspects of EC metabolism considering normal and diseased vasculature. Of relevance, we highlight that the implications of EC metabolism-targeted intervention (chiefly by metabolic enzymes or metabolites) could be harnessed in orchestrating a spectrum of pathological angiogenesis-associated diseases.

Keywords: Angiogenesis; Anti-tumor immunity; Cellular metabolism; Endothelial cell; Inflammation.

Publication types

Review