Abstract
Honokiol (HNK) is a typical natural biphenyl polyphenol compound. It has been proven to have a wide range of biological activities, including pharmacological effects such as anti-cancer, anti-inflammatory, neuroprotective, and antimicrobial. However, due to the poor stability, water solubility, and bioavailability of HNK, HNK has not been used in clinical treatment. This article reviews the latest research on the pharmacological activity of HNK and summarizes the HNK derivatives designed and improved by several researchers. Reviewing these contents could promote the research process of HNK and guide the design of better HNK derivatives for clinical application in the future.
Keywords:
Antitumor activity; Derivatives; Honokiol (HNK); Structural modification; Structure-activity relationship (SAR).
Copyright © 2024 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Allyl Compounds
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Animals
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Biphenyl Compounds* / antagonists & inhibitors
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Biphenyl Compounds* / chemistry
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Biphenyl Compounds* / pharmacology
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Humans
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Lignans* / chemical synthesis
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Lignans* / chemistry
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Lignans* / pharmacology
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Molecular Structure
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Neuroprotective Agents / chemical synthesis
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology
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Phenols
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Structure-Activity Relationship
Substances
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honokiol
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Lignans
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Biphenyl Compounds
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Antineoplastic Agents
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Neuroprotective Agents
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Anti-Inflammatory Agents
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Anti-Infective Agents
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Allyl Compounds
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Phenols