A novel dual near-infrared fluorescent probe for bioimaging and visualization of viscosity in acute alcoholic liver injury

Chem Commun (Camb). 2024 May 30;60(45):5804-5807. doi: 10.1039/d4cc01222d.

Abstract

A dual NIR fluorescent probe Cy-ND is developed for viscosity sensing with λex/em = 766/806 nm, making it apt for biological analysis, whose response is validated through DFT and TDDFT computations. Cy-ND successfully detected viscosity changes amidst acute alcohol-induced liver injury and liver ischemia-reperfusion injury.

MeSH terms

  • Animals
  • Carbocyanines / chemistry
  • Density Functional Theory
  • Fluorescent Dyes* / chemical synthesis
  • Fluorescent Dyes* / chemistry
  • Humans
  • Liver / diagnostic imaging
  • Liver Diseases, Alcoholic / diagnostic imaging
  • Mice
  • Optical Imaging
  • Reperfusion Injury / diagnostic imaging
  • Viscosity

Substances

  • Fluorescent Dyes
  • Carbocyanines