Exploring GPCR signaling pathway networks as cancer therapeutic targets

Balaji Santhanam; Madison Sluter; M Madan Babu

doi:10.1016/j.xgen.2024.100560

Exploring GPCR signaling pathway networks as cancer therapeutic targets

Cell Genom. 2024 May 8;4(5):100560. doi: 10.1016/j.xgen.2024.100560.

Authors

Balaji Santhanam¹, Madison Sluter², M Madan Babu³

Affiliations

¹ Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN 38120, USA. Electronic address: balaji.santhanam@stjude.org.
² Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN 38120, USA. Electronic address: madison.phelps@stjude.org.
³ Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN 38120, USA. Electronic address: madan.babu@stjude.org.

Abstract

GPCR signaling can contribute to establishing the tumor microenvironment and influence the progression and metabolism of tumors. Arora et al.¹ describe a systems-level approach to investigate the patterns of co-expression of GPCR signaling pathway networks across diverse tumors and identify network components that correlate with patient-survival data across different cancer types.

MeSH terms

Humans
Molecular Targeted Therapy / methods
Neoplasms* / drug therapy
Neoplasms* / metabolism
Receptors, G-Protein-Coupled* / metabolism
Signal Transduction*
Tumor Microenvironment

Substances

Receptors, G-Protein-Coupled