The Effectiveness of 23-valent Pneumococcal Polysaccharide Vaccine on Elderly Colorectal Cancer Long-Term Survivors: A population-based exact-matched cohort study

Hum Vaccin Immunother. 2024 Dec 31;20(1):2350093. doi: 10.1080/21645515.2024.2350093. Epub 2024 May 14.

Abstract

Colorectal cancer (CRC) long-term survivor is a rapid enlarging group. However, the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) on this group is unknown. This nationwide population-based study in Taiwan was designed to examine the effect of PPSV23 on incidence rate ratio (IRR) of pneumonia hospitalization, cumulative incidence, and overall survival rate for these long-term CRC survivors. This cohort study was based on the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database from 2000-2017. After individual exact matching to covariates with 1:1 ratio, there were a total of 1,355 vaccinated and 1,355 unvaccinated survivors. After adjusted by multivariate Poisson regression model, vaccinated group had a non-significantly lower pneumonia hospitalization risk than unvaccinated, with an adjusted IRR of 0.879 (p = .391). Besides, vaccinated group had both lower cumulative incidence rate and higher overall survival time than unvaccinated.

Keywords: Pneumococcal polysaccharide vaccine; colorectal cancer; hospitalization; pneumonia; survivor.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cancer Survivors* / statistics & numerical data
  • Cohort Studies
  • Colorectal Neoplasms* / mortality
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / mortality
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines* / administration & dosage
  • Pneumococcal Vaccines* / immunology
  • Registries
  • Survival Rate
  • Taiwan / epidemiology
  • Vaccination
  • Vaccine Efficacy

Grants and funding

We appreciate the research grants from the Dalin Tzu Chi Hospital [DTCRD 106(2)-I-19] and the Buddhist Tzu Chi Medical Foundation [TCMF-A 108-06]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the article.