Deciphering the triad of endothelial glycocalyx, von Willebrand Factor, and P-selectin in inflammation-induced coagulation

Guinevere Ferreira; Alexandra Taylor; Solomon A Mensah

doi:10.3389/fcell.2024.1372355

Deciphering the triad of endothelial glycocalyx, von Willebrand Factor, and P-selectin in inflammation-induced coagulation

Front Cell Dev Biol. 2024 Apr 30:12:1372355. doi: 10.3389/fcell.2024.1372355. eCollection 2024.

Authors

Guinevere Ferreira^{1

2}, Alexandra Taylor¹, Solomon A Mensah^{1

2}

Affiliations

¹ Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, MA, United States.
² Mechanical Engineering Department, Worcester Polytechnic Institute, Worcester, MA, United States.

Abstract

This review examines the endothelial glycocalyx's role in inflammation and explores its involvement in coagulation. The glycocalyx, composed of proteins and glycosaminoglycans, interacts with von Willebrand Factor and could play a crucial role in anchoring it to the endothelium. In inflammatory conditions, glycocalyx degradation may leave P-selectin as the only attachment point for von Willebrand Factor, potentially leading to uncontrolled release of ultralong von Willebrand Factor in the bulk flow in a shear stress-dependent manner. Identifying specific glycocalyx glycosaminoglycan interactions with von Willebrand Factor and P-selectin can offer insights into unexplored coagulation mechanisms.

Keywords: P-selectin; coagulation; endothelial glycocalyx; heparan sulfate; von Willebrand Factor.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Funding provided by the provost office and the department of biomedical engineering at WPI.