Real-World Study of Definisse Threads for Facial Reshaping in Indian Patients: REDEFINE FACE Study

Sukhbir Singh; Nitin Sethi; Malavika Kohli; V S Rathore; Indu Ballani; Madhuri Agarwal; Rickson Pereira; Shefali Trasi Nerurkar; Isha Kaushik; Sanjana Dadhich; Chetan Y Patil

doi:10.7759/cureus.58258

Real-World Study of Definisse Threads for Facial Reshaping in Indian Patients: REDEFINE FACE Study

Cureus. 2024 Apr 14;16(4):e58258. doi: 10.7759/cureus.58258. eCollection 2024 Apr.

Authors

Affiliations

¹ Plastic Surgery, Resplendent Cosmetic Studio, New Delhi, IND.
² Plastic Surgery, Fortis Hospital, Ludhiana, IND.
³ Dermatology, Skin Secrets, Jaslok Hospital & Research Centre, Mumbai, IND.
⁴ Plastic Surgery, Kaayakalp Clinic, Kolkata, IND.
⁵ Dermatology, BLK-Max Super Speciality Hospital, New Delhi, IND.
⁶ Dermatology, Yavana Aesthetic Clinic, Mumbai, IND.
⁷ Dermatology, Dr Rickson's Dermatherapie Clinic, Mumbai, IND.
⁸ Dermatology, Dr. Trasi's La Piel Skin Clinic, Mumbai, IND.
⁹ Medical Affairs, A. Menarini India Pvt Ltd, Delhi, IND.
¹⁰ Medical Affairs, A. Menarini India Pvt Ltd, Mumbai, IND.

Abstract

Introduction: In recent years, thread lifting has gained popularity as a less invasive cosmetic surgery. It helps raise and realign sagging tissue. The newest thread type for thread lifting procedure is poly-lactic acid-polycaprolactone (PLCL) Definisse threads (RELIFE S.r.l., Florence, Italy). These are fourth-generation absorbable suspended barbed threads. Their double action involves an immediate elevating impact through mechanical action and, over time, the promotion of histological rejuvenating activity through inducing fibroblasts and the synthesis of elastin, hyaluronic acid, and collagen.

Objectives: The REDEFINE FACE study assessed the effectiveness and tolerance of Definisse threads in a real-world setting for facial reshaping in patients in India.

Methods: This multicenter, retrospective observational research included patients treated with Definisse threads for face contouring.

Results: Three hundred seventeen patients with a mean follow-up of 4.9 months and an average age of 48.6 years participated in the study. All patients underwent thread lifts using either a single or a combination of Definisse thread reshaping techniques. The Global Aesthetic Improvement Scale for Physicians and Subjects (PGAIS and SGAIS) reported improvement instantly following the treatment (mean score- 3.23 and 3.18, respectively). Improvements continued to enhance during the follow-up visits (mean score- 4.09 and 4.03, respectively). Following the procedure, 96% of patients on the PGAIS and SGAIS exhibited enhancement. Most procedure-related side effects were minor and went away on their own in a few days without the need for proactive care.

Conclusion: The results of this real-world analysis showed that the latest Definisse threads effectively achieve facial reshaping on patients in India and have both immediate and long-term effects. Treatment was generally well tolerated, and no patient experienced serious adverse events.

Keywords: definisse threads; face lift; facial thread-lifting; thread lift; thread lifting.