Cysteine substitutants emerge in lung cancer proteomes during arginine restriction

Dennis J Hsu; Sohail F Tavazoie

doi:10.1016/j.molcel.2024.04.019

Cysteine substitutants emerge in lung cancer proteomes during arginine restriction

Mol Cell. 2024 May 16;84(10):1819-1821. doi: 10.1016/j.molcel.2024.04.019.

Authors

Dennis J Hsu¹, Sohail F Tavazoie²

Affiliations

¹ Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: djh138@pitt.edu.
² Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. Electronic address: stavazoie@rockefeller.edu.

PMID: 38759621
DOI: 10.1016/j.molcel.2024.04.019

Abstract

In this issue of Molecular Cell, Yang et al.¹ find that arginine-to-cysteine substitutants are enriched in a subset of lung cancer proteomes, potentiated by arginine deprivation, and promote resistance to chemotherapy.

MeSH terms

Arginine* / metabolism
Cysteine* / metabolism
Drug Resistance, Neoplasm / genetics
Humans
Lung Neoplasms* / drug therapy
Lung Neoplasms* / genetics
Lung Neoplasms* / metabolism
Lung Neoplasms* / pathology
Proteome* / metabolism