Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities

Hongjie Shao; Ye Li; Changhui Wu; Ruoyun Chen; Jie Kang

doi:10.1016/j.phytochem.2024.114148

Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities

Phytochemistry. 2024 May 18:224:114148. doi: 10.1016/j.phytochem.2024.114148. Online ahead of print.

Authors

Hongjie Shao¹, Ye Li², Changhui Wu², Ruoyun Chen¹, Jie Kang³

Affiliations

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing, 100050, China.
² Fujian Xianzhilou Biological Science and Technology Co. Ltd, 6 Chuangxin Road, High-Tech Zone, Fuzhou, 350108, China.
³ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing, 100050, China. Electronic address: jiekang@imm.ac.cn.

PMID: 38763311
DOI: 10.1016/j.phytochem.2024.114148

Abstract

Seven previously undescribed triterpenes (1-7), as well as one triterpene (8) previously described as a synthetic product, were isolated from the antler-shaped fruiting body of Ganoderma lucidum. Their structures were established based on comprehensive spectroscopy analysis. At a concentration of 10 μM, (24E)-3-oxo-15α-acetoxy-lanosta-7,9(11),24-trien-26-al (3) and (24R,25S)-3-oxo-lanosta-7,9(11)-dien-25-ethoxyl-24,26-diol (5) provided significant protection against acetaminophen-induced necrosis in human HepG2 liver cancer cells, and the cell survival rates were 69.7 and 76.1% respectively, similar to that of the positive control (glutathione, 72.1%). Based on the present results, these compounds could be potential hepatoprotective agents.

Keywords: Ganoderma lucidum (Leyss. ex Fr.) Karst; Hepatoprotection; Polyporaceae; Triterpenes.