Abstract
The antidepressant effects of amitriptyline and mesterolone, a synthetic androgen, were compared in a double-blind parallel treatment design. The drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Ambulatory Care
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Amitriptyline / adverse effects
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Amitriptyline / therapeutic use*
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Chronic Disease
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Clinical Trials as Topic
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Depressive Disorder / drug therapy*
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Depressive Disorder / psychology
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Dihydrotestosterone / analogs & derivatives*
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Double-Blind Method
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Humans
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Male
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Mesterolone / administration & dosage
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Mesterolone / adverse effects
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Mesterolone / therapeutic use*
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Middle Aged
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Psychiatric Status Rating Scales
Substances
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Dihydrotestosterone
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Mesterolone
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Amitriptyline