A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men

J Clin Psychiatry. 1985 Jan;46(1):6-8.

Abstract

The antidepressant effects of amitriptyline and mesterolone, a synthetic androgen, were compared in a double-blind parallel treatment design. The drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Ambulatory Care
  • Amitriptyline / adverse effects
  • Amitriptyline / therapeutic use*
  • Chronic Disease
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / psychology
  • Dihydrotestosterone / analogs & derivatives*
  • Double-Blind Method
  • Humans
  • Male
  • Mesterolone / administration & dosage
  • Mesterolone / adverse effects
  • Mesterolone / therapeutic use*
  • Middle Aged
  • Psychiatric Status Rating Scales

Substances

  • Dihydrotestosterone
  • Mesterolone
  • Amitriptyline