Abstract
Human blood lymphocytes were incubated for 24 hr in medium containing various therapeutic concentrations of the antiestrogenic drug Tamoxifen. This treatment resulted in a diminished expression of C'3-receptors on the cells as detected by a rosette technique (EAC-rosettes). The expression of membrane receptors for sheep red blood cells (SRBC) was not changed under the experimental conditions used.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Erythrocytes / immunology
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Female
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Humans
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In Vitro Techniques
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Lymphocytes / classification
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Lymphocytes / drug effects*
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Macrophage-1 Antigen
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Middle Aged
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Receptors, Complement / drug effects
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Receptors, Complement / metabolism
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Receptors, Immunologic / drug effects
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Rosette Formation
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Sheep
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Tamoxifen / pharmacology*
Substances
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Macrophage-1 Antigen
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Receptors, Complement
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Receptors, Immunologic
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Tamoxifen