Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

Pharmacol Ther. 1985;31(1-2):121-40. doi: 10.1016/0163-7258(85)90040-3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Line
  • Cross-Linking Reagents / pharmacology
  • DNA / drug effects*
  • DNA / metabolism
  • Humans
  • Leukemia / enzymology*
  • Leukemia / metabolism
  • Lymphocytes / enzymology
  • Lymphocytes / metabolism
  • Methyltransferases / isolation & purification*
  • Methyltransferases / metabolism
  • Nitroso Compounds / pharmacology*
  • O(6)-Methylguanine-DNA Methyltransferase

Substances

  • Cross-Linking Reagents
  • Nitroso Compounds
  • N-(2-chloroethyl)-N-nitrosoacetamide
  • DNA
  • Methyltransferases
  • O(6)-Methylguanine-DNA Methyltransferase