Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs

J Med Chem. 1977 Jul;20(7):925-30. doi: 10.1021/jm00217a012.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amides / chemical synthesis
  • Amides / metabolism
  • Amides / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Cells, Cultured
  • Chromatography, Thin Layer
  • Folic Acid Antagonists
  • Humans
  • Lacticaseibacillus casei / enzymology
  • Leukemia L1210 / metabolism
  • Leukemia, Experimental / metabolism
  • Leukemia, Lymphoid / metabolism
  • Liver / metabolism
  • Methotrexate / analogs & derivatives*
  • Methotrexate / chemical synthesis
  • Methotrexate / metabolism
  • Methotrexate / pharmacology
  • Mice
  • Rats

Substances

  • Amides
  • Antineoplastic Agents
  • Folic Acid Antagonists
  • Methotrexate