Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes

Arch Biochem Biophys. 1972 Oct;152(2):457-62. doi: 10.1016/0003-9861(72)90239-1.
No abstract available

MeSH terms

  • Aminopyrine N-Demethylase / biosynthesis
  • Animals
  • Benzopyrenes
  • Carbon Monoxide / pharmacology
  • Cyanides / pharmacology
  • Cytochrome P-450 Enzyme System / biosynthesis
  • Cytochrome c Group
  • Enzyme Induction
  • Female
  • Liver / anatomy & histology
  • Liver / drug effects
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / drug effects*
  • Mixed Function Oxygenases / biosynthesis*
  • Morphinans
  • Nitriles / pharmacology
  • Organ Size
  • Oxidoreductases / biosynthesis
  • Oxidoreductases, N-Demethylating / biosynthesis*
  • Phenobarbital / pharmacology
  • Pregnenolone / pharmacology*
  • Rats
  • Spectrophotometry

Substances

  • Benzopyrenes
  • Cyanides
  • Cytochrome c Group
  • Morphinans
  • Nitriles
  • Methylcholanthrene
  • Pregnenolone
  • Carbon Monoxide
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Oxidoreductases
  • Oxidoreductases, N-Demethylating
  • Aminopyrine N-Demethylase
  • Phenobarbital