Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide

MeSH terms

• Amides / chemical synthesis
• Amides / pharmacology
• Amides / toxicity
• Analgesics / chemical synthesis*
• Analgesics / pharmacology
• Analgesics / toxicity
• Animals
• Female
• Fentanyl / analogs & derivatives
• Fentanyl / chemical synthesis
• Fentanyl / pharmacology
• Lethal Dose 50
• Optical Rotation
• Phenylpropionates / chemical synthesis*
• Phenylpropionates / pharmacology
• Phenylpropionates / toxicity
• Piperidines / chemical synthesis*
• Piperidines / pharmacology
• Piperidines / toxicity
• Rats
• Reaction Time
• Stereoisomerism
• Structure-Activity Relationship