9 -tetrahydrocannabinol: dose-related effects on timing behavior in chimpanzee

Science. 1972 Feb 4;175(4021):547-50. doi: 10.1126/science.175.4021.547.

Abstract

Delta(9)-Tetrahydrocannabinol, at doses within the effective range for humans, was administered orally to chimpanzees with stable, efficient timing performances maintained by multilink chained schedules of food reinforcement. Reinforcements decreased with increasing dose, because of decreased frequencies of total operant timing responses and decreased accuracy of the timing performances which did occur. Higher doses exerted an effect for up to 3 days.

MeSH terms

  • Administration, Oral
  • Animals
  • Behavior, Animal / drug effects*
  • Cannabis / pharmacology*
  • Dronabinol / administration & dosage
  • Dronabinol / pharmacology
  • Pan troglodytes
  • Placebos
  • Time Factors
  • Time Perception / drug effects*

Substances

  • Placebos
  • Dronabinol