Abstract
Despite significantly elevated hypothalamic norepinephrine levels, genetically obese mice (ob/ob) had more hypothalamic alpha-adrenergic receptors than their lean littermates. This receptor increase appeared to be specific to the alpha-receptors in the hypothalamus since no change was found in the number of alpha-receptors in the cortex or in the dopamine and muscarinic receptors in the cortex and striatum.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenergic alpha-Antagonists / metabolism
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Animals
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Cerebral Cortex / metabolism
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Corpus Striatum / metabolism
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Dioxanes / metabolism
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Female
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Hypothalamus / metabolism*
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Kinetics
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Mice
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Mice, Obese
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Organ Specificity
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Receptors, Adrenergic / metabolism*
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Receptors, Adrenergic, alpha / metabolism*
Substances
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Adrenergic alpha-Antagonists
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Dioxanes
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Receptors, Adrenergic
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Receptors, Adrenergic, alpha
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(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane