Abstract
Suckling Swiss mice were injected daily for 8 days with either electrophoretically pure (EP) mouse interferon (s.a. 4.7 x 10(8) units/mg protein), major impurities obtained in the course of purification, or partially purified mouse interferon (s.a. 1.3 x 10(7) units/mg protein). Only EP or partially purified interferon inhibited growth, induced liver and kidney lesions, and killed mice. The authors conclude that interferon itself is responsible for these effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animal Population Groups / growth & development*
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Animals
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Animals, Suckling / growth & development*
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Electrophoresis
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Glomerulonephritis / etiology
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Histocytochemistry
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Interferons / isolation & purification
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Interferons / toxicity*
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Kidney / drug effects
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Kidney Diseases / etiology*
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Kidney Diseases / pathology
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Liver / drug effects
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Liver Diseases / etiology*
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Liver Diseases / pathology
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Mice
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Time Factors