Bilateral internuclear ophthalmoplegia after intrathecal chemotherapy and cranial irradiation

Am J Ophthalmol. 1981 Dec;92(6):851-3. doi: 10.1016/s0002-9394(14)75642-9.

Abstract

A 26-year-old man developed transient bilateral internuclear ophthalmoplegia with exotropia after cranial irradiation and intrathecal administration of methotrexate for lymphoma. Resolution of the ophthalmoplegia and the decrease in abnormally high levels of cerebrospinal fluid myelin basic protein after discontinuation of intrathecal medication suggested demyelination from chemotherapy and irradiation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Brain / radiation effects*
  • Humans
  • Injections, Spinal
  • Lymphoma, Non-Hodgkin / drug therapy
  • Lymphoma, Non-Hodgkin / radiotherapy
  • Lymphoma, Non-Hodgkin / therapy*
  • Male
  • Mediastinal Neoplasms / drug therapy
  • Mediastinal Neoplasms / radiotherapy
  • Mediastinal Neoplasms / therapy*
  • Myelin Basic Protein / physiology
  • Ophthalmoplegia / etiology*
  • Radiotherapy / adverse effects

Substances

  • Antineoplastic Agents
  • Myelin Basic Protein