Abstract
The sequence of two human beta-tubulin pseudogenes is described. One contains an intervening sequence but lacks sequences encoding the 55 N-terminal amino acids of the polypeptide chain. A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3' end, and it is flanked by a short direct repeat. These sequences have arisen by different mechanisms, including one that probably involves reverse transcription of a processed messenger RNA and reintegration of the complementary DNA copy into the genome.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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DNA / analysis
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DNA Restriction Enzymes
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DNA Transposable Elements
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DNA, Recombinant
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Gene Expression Regulation*
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Humans
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Nucleic Acid Hybridization
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Poly A / genetics
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RNA Splicing
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RNA-Directed DNA Polymerase / metabolism
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Recombination, Genetic
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Tubulin / genetics*
Substances
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DNA Transposable Elements
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DNA, Recombinant
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Tubulin
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Poly A
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DNA
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RNA-Directed DNA Polymerase
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DNA Restriction Enzymes
Associated data
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GENBANK/J00315
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GENBANK/J00316
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GENBANK/M24190
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GENBANK/M24191
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GENBANK/M24192